Association of TP53 polymorphism in lung cancer patient and healthy people in Bangladesh

sharif razon

Abstract


Lung cancer is one of the most common and lethal cancer. It’s most important etiologic factor is tobacco smoking. The p53 tumor suppressor protein is important in cell-cycle control, apoptosis, and DNA repair. Polymorphisms in TP53 have been associates with inherited cancer susceptibility. The association of p5 codon 72 polymorphisms with lung cancer has been investigated by several scientific groups with controversial results. However, the genotype distribution of p53 codon 72 polymorphisms as well as the association of this polymorphism with lung cancer risk remains undefined in the Bangladesh population. It has been reported that the genotype distribution of p53 codon 72 polymorphism of lung cancer patients and non-cancer controls and association of demographic characteristics with lung cancer. In a case control study, we frequently matched (by age, sex, and smoking) lung cancer patients and control subjects. TP53 Polymorphisms were determined by restriction fragment length Polymorphisms (RFLP) analysis of PCR amplified exon 4 of p53 gene. Nearly one-third of total lung cancer incidence in Bangladesh was squamous cell carcinoma subtype and increased frequency of Arg/Arg and Pro/Pro genotypes were associated with non-small cell lung cancer (NSCLC). The absence of Pro/Pro genotypes in non-smoker and association with low pack years smoking status suggested that Pro/Pro genotypes was more frequently affected by tobacco carcinogens, p53 polymorphism may be associated with increased lung cancer risk and may affect the function of p53 gene. The aim of this present review is to Investigation of the effect of smoking and TP53 polymorphism in developing lung cancer and Study the association of TP53 polymorphism in lung cancer patient and healthy people in Bangladesh.


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