Antimicrobial Activity of Mg Metal Chetates of 1, 2 Naphthoquinone Oxime Derivatives

J.M. Deshmukh, J.A. Patil, V.R. Sapre, S.P> Dagade, V.V. Dhapte

Abstract


Mg metal chelates of 1, 2 Naphthoquinone 1-oxime, 1, 2 Naphthoquinone 2-oxime and 1, 2 Naphthoquinone dioxime were synthesized and well characterized. The antimicrobial activity of these ligands and their metal chelates was determined by well diffusion method against Gram positive bacteria such as Staphylococcus aureus, Bacillus subtilis and Gram negative bacteria such as Escherichia coli and Salmonella typhi. Metal complexation often inhibits the growth of pathogenic bacteria. Mg complex was most effective against Gram +ve bacteria at concentration 2.0 mg/ml. Metal chelates may be useful tools for the understanding of antimicrobial mechanism of 1, 2 Naphthoquinone on these bacteria.


Keywords


1, 2 Naphthoquinone oximes, Metal chelates, Antimicrobial activity, Gram positive bacteria, Gram negative bacteria.

Full Text:

pdf

References


V. V. Dhapte, J. M. Deshmukh, S. P .Dagade, Vividha Dhapte., “Comparative study of 1, 2 Naphthoquinone oximes and their Cu (II) metal chelates” Asian Journal of Multidisciplinary Studies., Vol. 3, 27-31, Issue 12, December 2015.

Adriano Brandelli, Delmar Bizani, Marcia Martinelli, Valter Stefani, Annelise Engel Gerbase., “Antimicrobial activity of 1,4 Naphthoquinone by metal complexation.”, Revista Brasileira de Ciencias Farmaceuticas Brazilian Journal of Pharmaceutical Sciences., vol.40, n.2, Jun 2004

Xiaoxia Liu .Ph.D. Thesis., the university of HongKong 2000

Pritam Shinde, Smita Nilakhe,Vishwambhar Shinde,B.A. Kulkarni, V.R. Sapre, M.P. Wadekar., “Effect of Ring Isomerism on Spectral and Antimicrobial Studies of Sm(III)

Juglonates”., IOSR Journal of Applied Chemistry (IOSR-JAC) Volume 7, 33-40,. (2014)

N.R.Gonewar, V.B. Jadhav, S.S Sakure, K.D.Jadhav and R.G.Sarawadekar., “Thermal, X-ray Diffraction, spectral and antimicrobial activity of Bivalent Metal (Zn,Cd. Hg, Pb and Ag) chelate of 1,2 Naphthoquinone 2-oxime”., IOSR Journal of Pharmacy., Volume 3, PP. 10-17 ., Jan 2013

S Shukla R S Srivastava S K Shrivastava Ajit Sodhi Pankaj Kumar Synthesis, characterization and antiproliferative activity of 1,2-naphthoquinone and its derivatives., Applied biochemistry and biotechnology).; 167(5):1430-45. 2012

Glenworth , lamb; Standford and James.W, Clapp., Patent US 2, 935,440 May 1960

Bauer, A. W., D. M. Perry, and W. M. M. Kirby. 1959. Single disc antibiotic sensitivity testing of Staphylococci. A.M.A. Arch. Intern. Med. 104:208–216.


Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution 3.0 License.