Rifampicin induced fatal ventricular tachycardia, a case study.

B. B. Ballal, Renuka Ballal, Divya Chandrasekharan, Pooja Konde, Omkar Ghadge, M.G. Bodhankar


Rifampicin is a semisynthetic derivative of the naturally occurring Rifampicin SV. The drug binds with β subunit of bacterial RNA polymerase and in turn inactivates the RNA polymerase enzyme. It is the drug of choice for treating the infections of Mycobacterium spp., Methicillin Resistant Staphylococcus aureus (MRSA) and Methicillin Resistant Coagulase negative Staphylococci (CoNS). Eighty two years old hospitalized male patient was selected for the study. MRSS Staphylococcus aureus and Acinetobacter baumannii were isolated from sputum sample of the patient. He was treated for pyrexia, anorexia and dry cough with chemotherapeutic agents including rifampicin. Therapy of rifampicin induced fatal ventricular tachycardia in the patient. 


Rifampicin, Mycobacterium spp., Methicillin Resistant Staphylococcus aureus (MRSA), Methicillin Resistant Coagulase negative Staphylococci (CoNS), MRSS Staphylococcus aureus, Acinetobacter baumannii and ventricular tachycardia, Rifampicin induced cardiomy

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Aashish Pandit, Tarun Sachdeva and Pallavi Bafna‘‘Drug induced hepatotoxicity’’ (2011) A Review, Journal of Applied Pharmaceutical Science, 02(05):2012:233-243, ISSN: 2231-3354. DOI: 10.7324/JAPS.2012.2541

Carryn M. Anderson, M.D., Kenneth, J. Woodside, MD ,Todd A. Spencer, M.D and Glenn C. Hunter, M.D. Galveston, (2004) '' Methemaglobinaemia: An Unusual cause of postoperative cyanosis'' Journal. Vascular Surgeries; 39:6869.90.

Jacques Schrenzel, Stephen Harbarth, Gerard Schockme, Daniel Genne, Thomas Bregenzer, Ursula Flueckiger, Christiaane Petignat, Frederique Jacobs, Patrick Franciolli, Werner Zimmerli , Daniel Plew and the Swiss Staphylococcal Study Group (2004) ‘‘ A randomized clinical trial to compare Fleroxacin-Rifampicin with Flucoloxacillin or Vancomycin for treatment of Staphylococcal infection’’, Clinical Infectious Diseases, 39:1285-92.

James N. George et al. ‘‘Drug induced thrombocytopenia’’‘(1998): A systematic review of published case reports. Ann. Intern. Med.; 129:886-890.

Jerome A. Lindeboom, Lesla E. S. Bruijnesteijn van Coppenraet, Dick van Soolingen, Jan M. Prins and Eduard J. Kuijper ,‘‘Clinical Manifestations, Diagnosis, and Treatment of Mycobacterium haemophilum Infections’’ (Oct 2011), Clinical microbiology Reviews, p. 701-717, 0893-8512/11, doi: 10.1128/CMR.00020-11.

Pharmaceutical Microbiology, Edited by W. B. Hugo and A.D. Russell, Third Edition, Blackwell Scientific Publication, ISBN: 9971909596.

Rajiv Garg, V. Gupta, S. Mehra, R. Singh and R. Prasad. (2007) “Rifampicin induced thrombocytopenia “Indian Journal. Tuberculosis; 54:94-96.

Richardson J. H., Paul D Buisseret, ‘‘Myopathy induced by Rifampicin’’ (1981), British Medical Journal Volume 283, ISSN: 283(684).

Saubolle, M.A., T.E. Kiehn, M.H. White, M.F. Rudinsky and D. Armstrong (1996) ‘‘Mycobacterium haemophilum, Microbiology and expanding clinical and geographic spectra of disease in humans’’, Clinical Microbiology Review. 9:435-437.

Shah M. K. A. Sebti, T.E. Kiehn, S, A. Massarella and K.A. Sepkowitz (2001). ‘‘Mycobacterium haemophilum, in immunocompromised patients’’, Clinical Infectious Diseases 33:330-337.

Tostmann A, Boeree M.J., Aamoutse R. E., Lange W.C.M., Vander Ven A.J, Dekhuijzen R.(2008),‘‘Anti-tuberculosis drug induced hepatotoxicity’’ Journal of Gastroenterology and Hepatology. :23:192-202.


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