Cues Related Craving in Patients with Alcohol Dependence: An Electrophysiological Study
Electrophysiological methods, particularly event-related brain potentials (ERPs), have been used extensively to study the correlates and consequences of alcohol use and more direct method to measure attentional bias in patients with alcohol dependence. So keeping this in mind, the main aim of present study was to study the electrophysiological correlates of cues related craving in patients with alcohol dependence Method: In the present study, a sample of 30 patients with the diagnosis of mental and behavior disorder due to use of alcohol, currently using the substance (active dependence), and 20 normal controls matched on age and education were included. Data Interpretation: The analysis included descriptive statistics to see the severity of alcohol dependence includes (Mean, SD and Range) and Independent sample t-test which analyzed P300 amplitude and latency in relation to craving related cues between Patients with Alcohol Dependence and Normal Control Group. Results: Results shows that ERP parameters of P300 amplitude (in microvolt) in alcohol group had significantly higher amplitude for craving cues as compared to normal group. And on the other hand ERP parameters (before MET) of P300 latency (in milliseconds) shows that alcohol group had significantly longer latency as compared to normal group. Conclusion: So, on the basis of above findings it can be concluded that patients with alcohol dependence process craving related stimuli more efficiently than normal control.
Key Words: Electrophysiology, Craving, Alcohol Dependence
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