Frequency of Restless Legs Syndrome During Pregnancy in Lahore,Pakistan
Background: Restless legs syndrome is a neurological disease that impairs the quality of life causing sleep disturbance, anxiety and depression. This study was carried out to know the frequency of RLS during pregnancy.
Subjects and Methods: This cross sectional study was conducted at Gynaecology department………………………… After taking informed consent, data was collected using non-probability consecutive sampling technique from 300 pregnant women who came for ante-natal checkup in OPD during the first two weeks of May 2017. Diagnosis was made according to 2012 updated International Restless Legs Study Group Diagnostic Criteria. Data was entered and evaluated using SPSS version 20.
Results: Mean age of women was 25.75±3.28 years ranging from 20 to 36 years. Mean duration of pregnancy was 26.89±5.99 weeks ranging from 7 to 37 weeks. Ninety four of 300 (31.3%) women accomplished the diagnostic standard of RLS. Association of RLS with age and duration of pregnancy was found to be insignificant, p= 0.433, p= 0.257 respectively.
Conclusion: RLS is common in pregnant women.
Smith JE, Tolson JM. Recognition, diagnosis, and treatment of restless legs syndrome. J Am Acad Nurse Pract. 2008; 20: 396-401.
Aminoff MJ, Kerchner GA. Nervous system disorders. Papadakis MA, Mcphee SJ, Rabow MW, editors. Current medical diagnosis &treatment. Fifty fifth ed. Lange publishers, 2016; p.1001.
Hogl B, Kiechl S, Willeit J, Saletu M, Frauscher B, Seppi K, et al. Restless legs syndrome: a community based study of prevalence, severity and risk factors. Neurology. 2005; 64: 1920–4.
Ekbom KA. Restless legs syndrome. Acta Med Scand 1945; 158: 4-122.
Manconi M, Govoni V, Vito AD, Economon NT, Cesnik E, Casetta I, et al. Restless legs syndrome and pregnancy. Neurology. 2004;63:1065–9.
Tunc T, Karadag YS, Dogulu F, Inan LE. Predisposing factors of restless legs syndrome in pregnancy. MovDisord. 2007;22:627–31.
Allen RP, Picchietti DL, Garcia-Borreguero D, Ondo WG, Walters AS, Winkelman JW, et al. Restless legs syndrome/Willis-Ekbom disease diagnostic criteria: updated International Restless Legs Syndrome Study Group (IRLSSG) consensus criteria - history, rationale, description and significance. Sleep Med. 2014;15:860-73.
Alves DA, Carvalho LB, Morais JF, Prado GF. Restless legs syndrome during pregnancy in Brazilian women. Sleep Med. 2010;11:1049-54.
Neau JP, Marion P, Mathis S, Julian A, Godeneche G, Larrieu D, et al. Restless legs syndrome and pregnancy: follow-up of pregnant women before and after delivery. Eur Neurol. 2010; 64: 361-66.
Walters AS. Toward a better definition of the restless legs syndrome. The International Restless Legs Syndrome Study Group.MovDisord. 1995;10:634-42.
Facco FL, Kramer J, Ho KH, Zee PC, Grobman WA. Sleep disturbances in pregnancy. Obstet Gynecol. 2010; 115: 77-83.
Srivanitchapoom P, Pandey S, Hallett M. Restless legs syndrome and pregnancy: a review. Parkinsonism RelatDisord. 2014; 20: 716-22.
Pereira JC Jr, Pradella-Hallinan M, Lins Pessoa Hd. Imbalance between thyroid hormones and the dopaminergic system might be central to the pathophysiology of restless legs syndrome a hypothesis. Clinics (Sao Paulo). 2010;65:548-54.
Oyiengo D, Louis M, Hott B, Bourjeily G. Sleep disorders in pregnancy. Clin Chest Med. 2014;35:571-87.
Mindell JA, Cook RA, Nikolovski J. Sleep patterns and sleep disturbances across pregnancy. Sleep Med. 2015;16:483-88.
Romero R, Badr MS. A role for sleep disorders in pregnancy complications challenges and opportunities. Am J Obstet Gynecol. 2014;210:3-11.
Terzi H, Terzi R, Zeybek B, Ergenoglu M, Hacivelioglu S, Akdemir A, et al. Restless legs syndrome is related to obstructive sleep apnea symptoms during pregnancy. Sleep Breath. 2015;19:73-78.
Ramirez JO, Cabrera SA, Hidalgo H, Cabrera SG, Linnebank M, Bassetti CL, et al. Is preeclampsia associated with restless legs syndrome? Sleep Med. 2013;14:894-96.
Picchietti DL, Hensley JG, Bainbridge JL, Lee KA, Manconi M, McGregor JA, et al. International Restless Legs Syndrome Study Group (IRLSSG). Consensus clinical practice guidelines for the diagnosis and treatment of restless legs syndrome/Willis-Ekbom disease during pregnancy and lactation. Sleep Med Rev. 2015;22:64-77.
Picchietti DL, Wang VC, Picchietti MA. Intravenous iron given prior to pregnancy for restless legs syndrome is associated with remission of symptoms. J Clin Sleep Med. 2012;8:585-86.
Vadasz D, Ries V, Oertel WH. Intravenous iron sucrose for restless legs syndrome in pregnant women with low serum ferritin. Sleep Med. 2013;14:1214-16.
Sikandar R, Khealani BA, Wasay M. Predictors of restless legs syndrome in pregnancy a hospital based cross sectional survey from Pakistan. Sleep Med. 2009;10:676-78.
Rahman MM, Abe SK, Rahman MS, Kanda M, Narita S, Bilano V, et al. Maternal anemia and risk of adverse birth and health outcomes in low and middle income countries: systematic review and meta analysis. Am J Clin Nutr. 2016;103:495-504.
Suzuki K, Ohida T, Sone T, Takemura S, Yokoyama E, Miyake T, et al. Theprevalence of restless legs syndrome among pregnant women in Japan and the relationship between restless legs syndrome and sleep problems. Sleep. 2003;26:673-77.
Tunas T, Karadaay YS, Doayulu F, Inan LE. Predisposing factors of restlesslegs syndrome in pregnancy.MovDisord. 2007;22:627-31.
Manconi M, Govoni V, De Vito A, Economou NT, Cesnik E, Casetta I, et al. Restless legs syndrome and pregnancy. Neurology. 2004;63:1065-69.
Uglane MT, Westad S, Backe B. Restless legs syndrome in pregnancy is a frequent disorder with a good prognosis. ActaObstetGynecol Scand. 2011;90:1046-48.
Siddiqui S, Kavanagh D, Traynor J, Mak M, Deighan C, Geddes C. Risk factors for restless legs syndrome in dialysis patients. Nephron ClinPract. 2005;101:155-60.
- There are currently no refbacks.
This work is licensed under a Creative Commons Attribution 3.0 License.