Azithromycin and Ceftriaxone comparison in treating Enteric Fever

Dr. Atika Ahmed, Dr. Muhammad Fahad Aslam, Dr. Znaira Zeeshan


Objective: To analyze Azithromycin versus Ceftriaxone as far as interim taken (in number of days) fordefervescence youngsters suffering from enteric fever.

Place and Duration of Study: This observation was taken place at the Department of Paediatrics, Samnabad, Lahore from the month of August, 2018 up till Feburary, 2019.

Materials and Methods: An aggregate of 200 patients were chosen and separated into Group Aand Group B by lottery strategy. Non probability consecutive sampling technique was implemented.All of the patients in Group A were given dosage of oral azithromycin suspension/case (10mg/kg/day; most extreme portion, 500mg/day) once each day fora week and Group B with Intravenous (I/V) Ceftriaxone (75mg/kg/day; greatest place portion, 2.5 g/day) twice a day for 10 days. All drugs were controlled in the medical clinic by nursing staff. The Clinical reaction to the treatment of the two medications was determined as far as number of days taken for defervescence. Information were recorded in-predesignedpro-forma by specialist.

Results: Sex-distribution among the gatherings was irrelevant with p value=0.243.The general mean age of the patients was 4.21 ± 1.22 years. Defervescence savvy conveyance demonstrates that Group A have normal defervescence of 4.53 ± 1.57 days while in Group B it was 4.24 ± 1.22 days which was insignificant with p value = 0.728.

Conclusion: Mean defervescence time of azithromycin is superior to ceftriaxone in the treatment of enteric fever.

Keywords: Enteric fever, Azithromycin, Ceftriaxone.

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