Analysis of stone formation related to metabolic diseases and urinary tract infection
Objective. The main aim of this was to find the relation between stone formation in metabolic diseases and urinary tract infection caused by it.
Place and Duration of study: This study was carried out in urology department of Sheikh Zaid hospital Lahore in a duration of 9 months from March 2019 to November 2019.
Materials and Methods: A total of 100 patients were included in this study. Both genders were selected randomly. Every patient was asked to collect the urine sample for 24 hours which was then sent to a reliable laboratory for analysis of specific gravity, PH, uric acid, creatinine, calcium oxalate, phosphate, magnesium and citrate. Detailed history of each patient was taken. Plastic boxes which were inert were used to collect the samples and then stored at 2-8 ºC. Blood samples were also sent to look for the levels of creatinine, phosphate, urea, uric acid and calcium.
Results: Among the 100 patients selected 65 were females and 35 were male patients with the mean age of 38 years. 79% of the patients presented with the complaint of lumbar pain which was followed by burning micturition and hematuria. Ureteric of renal stones were diagnosed in 94% of the patients. Recurrent stone formation was seen in 38% of the cases while 62% of the patients suffered from it for the first time. Calcium oxalate was seen in 82.5% of the cases after detailed chemical analysis.Conclusion: The results obtained from our study shows that incidence of stone formation is very high in patients who have metabolic abnormalities and hypocitraturia, hyperoxaluria and hypercalciuria are the commonest abnormalities seen
Basiri A, Shakhssalim N, Khoshdel AR, Ghahestani SM, Basiri H. The demographic profile of urolithiasis in Iran: a nationwide epidemiologic study. IntUrolNephrol. 2010;42:119–126.
Kirac M, Kupeli B, Karaoglan U, Bozkirli I. Metabolic evaluation in patients with recurrent calcium oxalate stones. Turkish J Urol. 2011;37(3):246–251.
Johri N, Cooper B, Robertson W, Choong S, Rickards D, Unwin R. An update and practical guide to renal stone management. Nephron Clinic Practice. 2010;116(3):159–171.
Parvin M, Shakhssalem N, Basiri A, Miladipour AH, Golestan B, Torbati PM, et al. The most important metabolic risk factors in recurrent urinary stone formers. Urol J. 2011;8(2):99–106.
Elfadil GA, Ibrahim ME, Ahmed SAM. Metabolic Constituents of Urinary Stone Composition in Sudanese Children. Egypt Acad J biolog Sci. 2010;2(2):21–25.
Amaro CR, Golberg J, Agostinho AD, Damasio P, Kawano PR, Fugita OE, et al. Metabolic investigation of patients with staghorn calculus: it is necessary? IntBraz J Urol. 2009;35:658–663.
Shekarriz B, Stoller ML. Metabolic evaluation of stone disease. Brazil J Urol. 2001;27(1):10–18.
Majalan NN, Baghianimoghadam B, Amiri N, Moosavi SM. Metabolic abnormalities in patients with recurrent stone formation in a hot territory. BratislLekListy. 2010;111(2):79– 82.
Scales CD Jr, Curtis LH, Norris RD, Springhart WP, Sur RL, Schulman KA, et al. Changing gender prevalence of stone disease. J Urol. 2007;177:979–982
Androulakakis PA, Michael V, Polychronopoulou S, Aghioutantis C. Paediatricurolithiasis in Greece.Br J Urol. 1991;67(2):206–209.
Hess B, Hasler-Strub U, Ackermann D, Jaeger P. Metabolic evaluation of patients with recurrent idiopathic calcium nephrolithiasis. Nephrol Dial Transplant. 1997;12:1362–1368.
Coenye T., Nelis H. J. In vitro and in vivo model systems to study microbial biofilm formation. Journal of Microbiological Methods. 2010;83(2):89–105.
Ghanwate N. A., V Thakare P., Bhise P. R., Tayde S. Prevention of biofilm formation in urinary catheters by treatment with antibiofilm agents. International Journal of Science and Research. 2014;3(4):2–5.
Estores I. M., Olsen D., Gomez-Marin O. Silver hydrogel urinary catheters: evaluation of safety and efficacy in single patient with chronic spinal cord injury. Journal of Rehabilitation Research and Development. 2008;45(1):135–139.
Townsley L., Shank E. A. Natural-product antibiotics: cues for modulating bacterial biofilm formation. Trends in Microbiology. 2017;25(12):1016–1026.
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