The effects of a Acute Bout of Exhaustive Treadmill Exercise on malondialdehyde, level in rat liver
The aim of this study was to investigate whether 8-week treadmill training attenuates exercise-induced oxidative stress in rat liver. Materials and methods: The study was carried out with 12 week-old male rats (N =24) were divided into untrained and trained groups. Endurance training consisted of treadmill running at a speed of 25 m/min for 1 h/day and 10% uphill grade 5 days a week for 8 weeks. To see the effects of endurance training on acute exhaustive exercise induced oxidative stress, untrained and trained rats were further divided into two groups: animals killed at rest and those killed after acute exhaustive exercise, in which the rats run at 30 m/min (10% uphill) until exhaustion. Results: After a single bout of exhaustive treadmill running, malondialdehyde level in untrained and trained rats were significantly increased, but were significantly lower in the trained group. Conclusions: The results suggested that single bout of exhaustive treadmill exercise may induce liver damage and endurance training attenuated exercise-induced oxidative stress in liver after a single bout of exhaustive treadmill running, probably by reinforced of antioxidant defense system during exercise.
Aksoy, Y., T. Yapanoglu, et al. (2006). "Effects of endurance training on antioxidant defense mechanisms and lipid peroxidation in testis of rats." Systems Biology in Reproductive Medicine 52(4): 319-323.
Ames, B. N., M. K. Shigenaga, et al. (1993). "Oxidants, antioxidants, and the degenerative diseases of aging." Proceedings of the National Academy of Sciences 90(17): 7915-7922.
Bradford, M. M. (1976). "A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding." Analytical biochemistry 72(1): 248-254.
Brooks, G. A. and T. P. White (1978). "Determination of metabolic and heart rate responses of rats to treadmill exercise." Journal of applied physiology 45(6): 1009-1015.
Çakır, B., Ö. Kasımay, et al. (2010). "Stress‐induced multiple organ damage in rats is ameliorated by the antioxidant and anxiolytic effects of regular exercise." Cell biochemistry and function 28(6): 469-479.
Caraceni, P., E. R. Rosenblum, et al. (1994). "Reoxygenation injury in isolated rat hepatocytes: relation to oxygen free radicals and lipid peroxidation." American Journal of Physiology-Gastrointestinal and Liver Physiology 266(5): G799-G806.
Carnethon, M. R., S. S. Gidding, et al. (2003). "Cardiorespiratory fitness in young adulthood and the development of cardiovascular disease risk factors." Jama 290(23): 3092-3100.
Choi, E.-Y. and Y.-O. Cho (2007). "The effects of physical training on antioxidative status under exercise-induced oxidative stress." Nutrition research and practice 1(1): 14-18.
Davies, K. J., A. T. Quintanilha, et al. (1982). "Free radicals and tissue damage produced by exercise." Biochemical and biophysical research communications 107(4): 1198-1205.
Esterbauer, H., R. J. Schaur, et al. (1991). "Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes." Free Radical Biology and Medicine 11(1): 81-128.
Fojt, E., L.-G. Ekelund, et al. (1976). "Enzyme activities in hepatic venous blood under strenuous physical exercise." Pflügers Archiv 361(3): 287-296.
Gunduz, F., U. Senturk, et al. (2004). "The effect of one year swimming exercise on oxidant stress and antioxidant capacity in aged rats." Physiological Research 53(2): 171-176.
Hoene, M. and C. Weigert (2010). "The stress response of the liver to physical exercise." Exercise immunology review 16.
Huang, C.-C., T. Lin, et al. (2009). "Protective effects of L-arginine supplementation against exhaustive exercise-induced oxidative stress in young rat tissues."
Huang, C.-C., S.-C. Tsai, et al. (2008). "Potential ergogenic effects of L-arginine against oxidative and inflammatory stress induced by acute exercise in aging rats." Experimental gerontology 43(6): 571-577.
Jackson, M. J., S. Papa, et al. (2002). "Antioxidants, reactive oxygen and nitrogen species, gene induction and mitochondrial function." Molecular aspects of medicine 23(1): 209-285.
Ji, L. (1995). "Oxidative stress during exercise: implication of antioxidant nutrients." Free Radical Biology and Medicine 18(6): 1079-1086.
Kon, M., F. Kimura, et al. (2007). "Effect of Coenzyme Q10 supplementation on exercise-induced muscular injury of rats." Exerc Immunol Rev 13: 76-88.
Korivi, M., C.-W. Hou, et al. (2011). "Ginsenoside-Rg1 protects the liver against exhaustive exercise-induced oxidative stress in rats." Evidence-Based Complementary and Alternative Medicine 2012.
Laaksonen, D. E., M. Atalay, et al. (2002). "Effects of endurance training on tissue glutathione homeostasis and lipid peroxidation in streptozotocin‐induced diabetic rats." Scandinavian journal of medicine & science in sports 12(3): 163-170.
Latour, M. G., A. Brault, et al. (1999). "Effects of acute physical exercise on hepatocyte volume and function in rat." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 276(5): R1258-R1264.
Leeuwenburgh, C. and L. L. Ji (1995). "Glutathione depletion in rested and exercised mice: biochemical consequence and adaptation." Archives of Biochemistry and Biophysics 316(2): 941-949.
Lew, H., S. Pyke, et al. (1985). "Changes in the glutathione status of plasma, liver and muscle following exhaustive exercise in rats." FEBS letters 185(2): 262-266.
Liu, J., H. C. Yeo, et al. (2000). "Chronically and acutely exercised rats: biomarkers of oxidative stress and endogenous antioxidants." Journal of Applied Physiology 89(1): 21-28.
Lovlin, R., W. Cottle, et al. (1987). "Are indices of free radical damage related to exercise intensity." European journal of applied physiology and occupational physiology 56(3): 313-316.
Mallikarjuna, K., K. Nishanth, et al. (2009). "Effect of exercise training on ethanol-induced oxidative damage in aged rats." Alcohol 43(1): 59-64.
McCord, J. (1987). Oxygen-derived radicals: a link between reperfusion injury and inflammation. Federation proceedings.
Miyazaki, H., S. Oh-ishi, et al. (2001). "Strenuous endurance training in humans reduces oxidative stress following exhausting exercise." European journal of applied physiology 84(1-2): 1-6.
Navarro, A., C. Gomez, et al. (2004). "Beneficial effects of moderate exercise on mice aging: survival, behavior, oxidative stress, and mitochondrial electron transfer." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 286(3): R505-R511.
Oh-Ishi, S., T. Kizaki, et al. (1997). "Endurance training improves the resistance of rat diaphragm to exercise-induced oxidative stress." American journal of respiratory and critical care medicine 156(5): 1579-1585.
Ohnishi, K., M. Saito, et al. (1985). "Portal venous hemodynamics in chronic liver disease: effects of posture change and exercise." Radiology 155(3): 757-761.
Radák, Z., H. Y. Chung, et al. (2004). "Age-associated increase in oxidative stress and nuclear factor κB activation are attenuated in rat liver by regular exercise." The FASEB journal 18(6): 749-750.
Radák, Z., H. Naito, et al. (2002). "Exercise training decreases DNA damage and increases DNA repair and resistance against oxidative stress of proteins in aged rat skeletal muscle." Pflügers Archiv 445(2): 273-278.
Rowell, L. B., J. R. Blackmon, et al. (1964). "Indocyanine green clearance and estimated hepatic blood flow during mild to maximal exercise in upright man." Journal of Clinical Investigation 43(8): 1677.
Sen, C. K., E. Marin, et al. (1992). "Skeletal muscle and liver glutathione homeostasis in response to training, exercise, and immobilization." Journal of Applied Physiology 73(4): 1265-1272.
Sen, C. K. and L. Packer (2000). "Thiol homeostasis and supplements in physical exercise." The American journal of clinical nutrition 72(2): 653s-669s.
Taysi, S., N. Oztasan, et al. (2008). "Endurance training attenuates the oxidative stress due to acute exhaustive exercise in rat liver." Acta Physiologica Hungarica 95(4): 337-347.
Turgut, G., S. Demir, et al. (2002). "The effect of swimming exercise on lipid peroxidation in the rat brain, liver and heart." Acta physiologica et pharmacologica Bulgarica 27(2-3): 43-45.
Veneroso, C., M. J. Tuñón, et al. (2009). "Melatonin reduces cardiac inflammatory injury induced by acute exercise." Journal of pineal research 47(2): 184-191.
Villa, J., M. Almar, et al. (1993). "Impairment of bile secretion induced by exhaustive exercise in the rat." International journal of sports medicine 14(04): 179-184.
VinÑa, J., M. C. Gomez‐Cabrera, et al. (2000). "Free radicals in exhaustive physical exercise: mechanism of production, and protection by antioxidants." IUBMB life 50(4‐5): 271-277.
Yano, H., S. Kinoshita, et al. (1997). "Acute exercise induces mitochondrial swelling of hepatocytes surrounding the terminal hepatic venule in rat liver acinus." Japanese The Journal of Sports Medicine and Physical Fitness 46(1): 49-54.
Yano, L., H. Yano, et al. (1996). "Electromagnetic determination of portal venous flow in rats during exercise." International hepatology communications 5(3): 184-190.
- There are currently no refbacks.
This work is licensed under a Creative Commons Attribution 3.0 License.