Change in the Malondialdehyde status of heart following exhaustive exercise in Rats

bijan GOODARZI, AMIR KHOSRAVI

Abstract


The aim of this study was to investigate of  eight weeks treadmill training attenuates exercise-induced oxidative stress in rat heart. The study was carried out with 12 week-old male rats (N =24) were divided into untrained and trained groups. Endurance training consisted of treadmill running at a speed of 25 m/min for 1 h/day and 10% uphill grade 5 days a week for 8 weeks. To see the effects of endurance training on acute exhaustive exercise induced oxidative stress, untrained and trained rats were further divided into two groups: animals killed at rest and those killed after acute exhaustive exercise, in which the rats run at 30 m/min (10% uphill) until exhaustion.

After a single bout of exhaustive treadmill running, malondialdehyde level in untrained and trained rats were significantly increased, but were significantly lower in the trained group. Conclusions: The results suggested that single bout of exhaustive treadmill exercise may induce heart damage and endurance training attenuated exercise-induced oxidative stress in heart after a single bout of exhaustive treadmill running, probably by reinforced of antioxidant defense system during exercise.

Keywords


acute exercise, oxidative stress, heart

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References


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