Change in the Malondialdehyde status of heart following exhaustive exercise in Rats



The aim of this study was to investigate of  eight weeks treadmill training attenuates exercise-induced oxidative stress in rat heart. The study was carried out with 12 week-old male rats (N =24) were divided into untrained and trained groups. Endurance training consisted of treadmill running at a speed of 25 m/min for 1 h/day and 10% uphill grade 5 days a week for 8 weeks. To see the effects of endurance training on acute exhaustive exercise induced oxidative stress, untrained and trained rats were further divided into two groups: animals killed at rest and those killed after acute exhaustive exercise, in which the rats run at 30 m/min (10% uphill) until exhaustion.

After a single bout of exhaustive treadmill running, malondialdehyde level in untrained and trained rats were significantly increased, but were significantly lower in the trained group. Conclusions: The results suggested that single bout of exhaustive treadmill exercise may induce heart damage and endurance training attenuated exercise-induced oxidative stress in heart after a single bout of exhaustive treadmill running, probably by reinforced of antioxidant defense system during exercise.


acute exercise, oxidative stress, heart

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