The effects of aerobic training on malondialdehyde level of brain premotor cortex of young male rats following an acute bout of exhaustive endurance exercise

Amir Khosravi


Introduce: Physical exercise is a widely accepted behavioral strategy to enhance overall health, including mental function. However, there is controversial evidence showing brain mitochondrial dysfunction, oxidative damage after high-intensity exercise, which presumably worsens cognitive performance.

Purpose: The aim of this study was to investigate whether 8-week treadmill training could modulate exercise-induced oxidative stress in the brain premotor cortex of rats following an acute bout of exhaustive endurance exercise.

Methods: For this reason the study was carried out with 12 week-old male rats (N =32) were randomly divided into two groups (N=16): non-runners control (SED), running exercise (ET).The exercise schedule consisted of progressive treadmill running for 5 days week-1 over 8 weeks. To see the effects of endurance training on acute exhaustive exercise induced oxidative stress, (SED) and (ET) rats were further divided into two groups: animals killed at rest and those killed after an acute bout of exhaustive endurance exercise, in which the rats run at 30 m/min (10% uphill) until exhaustion.

Results:After a single bout of exhaustive treadmill running, increased significantly the lipid peroxidation level of brain premotor cortex in (SED) and (ET) rats (p<0.05).

Conclusion: As a result, it is concluded that the performed 8 weeks exercise could not prevented the increased significantly the lipid peroxidation level of brain premotor cortex response to acute bout of exhaustive exercise. These results indicate that intense exercise can have some deleterious effect on brain premotor cortex.


acute exercise, oxidative stress, brain premotor cortex

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